LYL activity is required for the maturation of newly formed blood vessels in adulthood Running Title : LYL and blood vessel maturation
نویسندگان
چکیده
Institut de Génétique Moléculaire de Montpellier UMR 5535 CNRS, 1919 route de Mende, 34293 Montpellier cedex 5; Université Montpellier 2, Place Eugène Bataillon, 34095 Montpellier cedex 5; Université Montpellier 1, 5 Bd Henry IV, 34967 Montpellier cedex 2, FRANCE. Institute of Genetics, The University of Nottingham, School of Biology, Queen’s Medical Center, Nottingham NG7 2UH, UK. Novartis Institute for Biomedical Research (NIBR), Investigative Toxicology, Basel, Switzerland. Present address: Institut de Recherche en Cancérologie de Montpellier, 208 Rue des Apothicaires 34298, Montpellier Cedex5, FRANCE.
منابع مشابه
The SCL relative LYL-1 is required for fetal and adult hematopoietic stem cell function and B-cell differentiation.
Hematopoietic stem cells (HSCs) arise, self-renew, or give rise to all hematopoietic lineages through the effects of transcription factors activated by signaling cascades. Lyl-1 encodes a transcription factor containing a basic helix-hoop-helix (bHLH) motif closely related to scl/tal, which controls numerous decisions in embryonic and adult hematopoiesis. We report here that Lyl-1 null mice are...
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